Two hundred years after Mary Shelley's novel the brilliant but mad Doctor (Thomas Kretschmann) has sustained his creature and himself over two centuries through genetic experimentation. In present-day America Detective O'Connor (Parker Posey) is investigating a series of horrific murders which leads her to the doctor and his creature. What she uncovers reveals the strange evolution the doctor and his creation undergo over the course of two centuries and the divergent paths creator and monster take in pursuing good or evil.
在玛丽·雪莱的小说两百年后,才华横溢但疯狂的医生使他自己和他的怪物从两个世纪前确当初的尝试一向幸存下来。现在,美国捕快 O'Connor 在观察系列谋杀案时,被引向了医生和他的怪物,并揭穿出在长达两个多世纪的冗长光阴中,医生和他作品间的奇异演变和他们踏上善与恶的分歧门路。